ABSTRACT
Background: Periodontitis is a severe form of gum disease which in flames and destroys tissues supporting the teeth and leading to potential loss of teeth. If untreated, it could lead to heightened risk of serious health issues and other complicati…
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…ons. This study was performed to meta-analyze
gene expression data from Periodontitis infected samples to possibly identify clinically targetable
genes associated with Periodontitis.
Methods: This study defined 8 gene signatures between Periodontitis infected and mock infected
from 2 datasets and compared them through Gene Set Enrichment Analysis (GSEA). Positive
and negative panels were defined from GSEA identified leading-edge genes in each query set.
GSEA was then utilized to calculate enrichment and identify differentiation in gene expression of
Periodontitis and compared it with other gene signatures.
Results: GSEA identified 93 and 127 probes, representing 71 and 114 unique positive and
negative panels, respectively, from the GSE10334 dataset. Also, GSEA identified 110 and 112
probes, representing 92 and 108 unique positive and negative panels, respectively, from the
GSE16134 dataset. Non-random significant enrichment was observed between each identified
panel and all verification gene signatures derived from both datasets and 23 overexpressed and
33 under expressed genes were found out to be shared across all verification gene signatures.
The final genes identified to have significant association with Periodontitis consisted of few genes
that were found to be associated with periodontitis in previous studies and also showed new
genes that have not been identified to have connection with periodontitis previously.
Conclusion: Gene Set Enrichment Analysis identified genes associated with Periodontitis with
prior or no prior known connection with Periodontitis. These results might be useful as potential
therapeutic targets for Periodontitis disease.
Full Text/Reference Website: https://www.cscjournals.org/library/manuscriptinfo.php?mc=IJBB-271
AUTHORS
Dr. Laura K. Harris – Lumiere Education Inc. Wilmington, 48824 – United States of America
Mr. Mingi Kim – Harris Interdisciplinary Education, Dewitt, 48820
Lumiere Education Inc., Wilmington, 48824 – United States of America
KEYWORDS
Periodontitis, Microarray, Gene Expression, Meta-Analysis, Gene Set Enrichment Analysis.
Indexing Keywords: Gene Expression Meta-Analysis Reveals Gene Associated with Periodontitis, Gene Expression Meta-Analysis, Meta-Analysis Gene Associated with Periodontitis, Gene Associated with Periodontitis, Meta-Analysis Reveals Gene Associated.
Pages: 1-17
Revised: 31-01-2024
Published: 29-02-2024Published in International Journal of Biometrics and Bioinformatics (IJBB).
Volume: 17
Issue: 1
Publication Date: 29-02-2024
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